Table III. Topics covered in the core courses of the immunology major
Introduction to immunology
 Basics of hematopoiesis
 Categories of cell types, characteristics, and functions
 Anatomy of the lymphoid organs and tissues
 Trafficking of leukocytes throughout the body
 Properties of receptor–ligand interactions
 Characteristics of signaling molecules and tyrosine-dependent pathways
Innate immune responses
 Functional elements: barriers, cells, tissues, and soluble mediators
 Characteristics, functions, and activation mechanisms of innate immune cells
 Pattern recognition receptors, pathogen/damage–associated molecular patterns
 Mechanisms of extravasation, phagocytosis, and pathogen destruction
 Function and components of the inflammatory response
 Activation and functions of the acute phase response
 Activation, regulation, and functions of the complement system
 Cooperation of complement and the inflammatory response in the elimination of pathogens
 The role of NK cells and the IFN response in eliminating viral pathogens
 Processes performed by innate immune cells that result in the activation of the adaptive response to a pathogen
Lymphocyte development and activation
 Functional components of lymphocyte AgR
 Organization and expression of lymphocyte AgR genes
 BCR and TCR gene rearrangements
 Processes of B and T cell development from a stem cell to a mature cell
 Structure, function, and expression patterns of classical MHC molecules
 The role of APC and Ag processing and presentation pathways in T lymphocyte activation
 Mechanisms of B cell activation by T-independent and T-dependent Ags
 Ab structure, structural isoforms, isotypes, and Ag–Ab interactions
Humoral and cell-mediated immune responses
 T-independent B cell responses
 T-dependent B cell responses, linked recognition, generation of high-affinity Ab production, and class switching
 Ab-mediated effector functions
 The role of APC and cytokines on the differentiation of T cell subsets
 CD4+ T cell–mediated functions
 CD8+ T, NK, and NKT cell functions
 Characteristics and function of memory responses
  • The core topics that form the basis of the content delivery frame are listed in this table.