Table II. Top 20 cytokines/chemokines altered in lung macrophages with P. aeruginosa EV treatment
Normalized Read Counts (±SD)a
GeneUntreatedEV Treated (48 h)
IL-1α170 (80)3,661 (960)
IL-1β370 (248)27,130 (11,310)
IL-63.3 (4.3)1,810 (1,230)
IL-81,502 (1,793)102,843 (43,186)
IL-101.6 (0.6)69 (44)
IL-191.0 (0.1)679 (386)
TGF-β1338 (33)388 (74)
TNF37 (21)357 (153)
CCL2 (MCP-1)48 (29)3,861 (1,882)
CCL3 (MIP-1α)3,653 (452)10,822 (6,354)
CCL4 (MIP-1β)183 (246)4,136 (2,493)
CCL7 (MCP-3)4.6 (4.2)226.5 (144.3)
CCL18 (MIP-4)14,051.3 (10,181.1)5,355.1 (4,644.1)
CCL20 (MIP-3α)152.8 (221.1)8,081.9 (4,137.4)
CCL23 (MIP-3)270.6 (195.8)71.5 (34.2)
CXCL1 (GROα)83.6 (138.9)31,247.4 (18,633.5)
CXCL2 (GROβ)146.0 (92.1)5,344.8 (4,184.8)
CXCL3 (GROγ)290.9 (276.0)16,089.7 (8,477.7)
CXCL5 (ENA-78)1,765.1 (2,118.8)40,783.8 (6,306.1)
CXCL16 (SRPSOX)1,325.7 (1,792.7)2,589.1 (541.1)
  • n = 7 subjects.

  • a NanoString PanCancer/Immunology gene expression assay.