Table I. Top EPIC CpGs with differential methylation in upper lobe macrophages associated with genes of known function
NameChromosomeCoordinateStrandUCSC Ref Gene GroupGeneΔβ valuep ValueFDR p Value
cg22265796chr1916254043+5′-UTRHSH2D0.10704.05 × 10−60.013
cgl9307883chr1910484624+BodyTYK20.10388.89 × 10−60.017
cg07676849chr1171845665TSS1500FOLR30.07471.02 × 10−50.018
cgl7323256chr12524458975′-UTR/BodyNR4A10.05071.33 × 10−50.019
cg00889217chr129233083BodyA2M−0.0821.98 × 10−50.026
cgl3427753chr645406009BodyRUNX20.0494.76 × 10−50.032
cg25648980chr1251719079+TSS1500BIN20.04844.77 × 10−50.032
cg02290197chr726370519+5′-UTRSNX100.05083.90 × 10−50.032
cgl1259727chr21754652975′-UTRW1PF10.05164.33 × 10−50.032
cgl8255141Chr126487113TSS1500SCNN1A0.07424.79 × 10−50.032
cgl6711835chr5595584675′-UTRPDE4D0.07473.80 × 10−50.032
cg14975420Chr1091096289+5′-UTR/BodyIFIT30.04795.95 × 10−50.033
cg06086177chr1673090646+5′-UTRZFHX30.04657.92 × 10−50.038
cgl3126638Chr126487080+TSS1500SCNN1A0.05451.01 × 10−40.040
cg26118047chr229320360+TSS200CLIP40.05901.40 × 10−50.046
  • Δβ, increase in the proportion of methylated alleles in upper lobe cells; TSS, transcription start site; UCSC, University of California, Santa Cruz.