Table I. Relationship between epitope specificity and TNA
mAbaIsotypeKDbIC50cIn VivodRTA Contact Pointse
a and Ad and eD and EF and G
PH12IgG190.089/10++
TB12IgG1420.119/10++
LE4IgG1370.39/11++
CH1IgG195>102/11+
SWB1IgG1200>101/5+
PA1IgG190.071/11+
6C4IgG1470>102/11++
WECH1IgG13701.71/11++
SyH7IgG1200.70/10++
  • a Underlines indicate the five new mAbs described in this study, whereas bold indicates passive protection up to day 7.

  • b Apparent binding affinities (×10−12 M).

  • c Micrograms per milliliter, as determined in Vero cell assay.

  • d Indicates number of survivors/total number in group.

  • e Secondary structures on RTA associated with each mAb’s epitope. As per convention, capital letters refer to α-helices, and lowercase letters refer to β-strands.