Table I. Expression levels of transcripts encoding enzymes associated with arginine metabolism and the production of NO
Gene NameDescriptionRNA-Seq
SheepGoatCattleBuffalo
0 h7 h0 h7 h0 h7 h0 h7 h
ARG1Arginase 10.040.052.642.736.055.840.020.01
ARG2Arginase 27.4056.2711.8241.0648.48347.9930.06153.54
ASLArgininosuccinate lyase31.4814.7525.4017.7838.2117.9919.726.50
ASS1Argininosuccinate synthase 119.3910.184.383.7210.717.650.050.32
GCH1GTP cyclohydrolase 117.1432.888.3110.1522.9486.9813.6610.90
NOS2NO synthase 2, inducible0.5519.093.7819.692.14901.203.25301.37
OATOrnithine aminotransferase362.00324.62164.61167.151166.67854.75204.40142.74
ODC1Ornithine decarboxylase 192.12269.73340.63376.0145.4618.26119.0253.83
PTS6-pyruvoyltetrahydropterin synthase17.4913.6662.0162.6127.5311.9136.3616.32
SLC3A2Solute carrier family 3, member 2161.19167.79209.91210.1198.2062.87168.22146.74
SLC7A1Solute carrier family 7, member 17.9110.0238.0845.947.376.9919.9549.59
SLC7A2Solute carrier family 7, member 20.010.045.8815.730.040.180.182.03
SLC7A5Solute carrier family 7, member 59.0121.67115.47106.675.833.467.747.46
SLC7A7Solute carrier family 7, member 7283.90161.32109.1360.78220.58120.25114.72103.68
SPRSepiapterin reductase21.0013.8078.29124.3020.474.6037.2813.15
Gene NameDescriptionRNA-SeqCAGE
HorsePigRatHuman
0 h7 h0 h7 h0 h7 h0 h7 h
ARG1Arginase 10.100.0570.62379.1176.631041.600.000.00
ARG2Arginase 2119.2359.7213.5611.913.351.883.101.30
ASLArgininosuccinate lyase24.0614.4813.9310.3569.6350.245.800.70
ASS1Argininosuccinate synthase 125.8520.340.020.042.38250.120.000.00
GCH1GTP cyclohydrolase 124.7731.899.829.6724.17189.570.70391.00
NOS2NO synthase 2, inducible0.000.010.661.7759.034961.790.000.00
OATOrnithine aminotransferase103.5668.8195.7483.74104.9382.1083.0057.00
ODC1Ornithine decarboxylase 198.4839.73241.26195.9364.5545.635.301.30
PTS6-pyruvoyltetrahydropterin synthase27.9816.30143.49141.3011.5113.010.500.00
SLC3A2Solute carrier family 3, member 2168.35120.18238.46248.84191.23289.86115.00123.00
SLC7A1Solute carrier family 7, member 113.279.725.454.6820.0214.000.000.00
SLC7A2Solute carrier family 7, member 20.010.051.000.4746.31843.810.000.00
SLC7A5Solute carrier family 7, member 58.977.2813.098.8117.7114.762.7075.00
SLC7A7Solute carrier family 7, member 757.1246.60136.68198.9916.9716.0071.0025.00
SPRSepiapterin reductase10.203.5513.088.2610.089.9521.001.80
  • Expression levels are represented as TPM, and are mean values for each condition from multiple animals. Sheep, n = 6; goat, n = 3; buffalo, n = 4; cattle, n = 4; horse, n = 3; pig, n = 3; rat, n = 3; human, n = 3. Human data were generated by CAGE-seq, as previously described (10), and all other data were generated by RNA-seq as described.