Table II. HBsAg-specific bulk cytokine secretion stratified by humoral immune response to primary immunization against HBV at age 1 and 2 y

CMI Parameter at 1 y	Low-Responders at 1 y (n = 16)	High-Responders at 1 y (n = 57)	p Value	Nonresponders at 2 y (n = 15)	Low- Responders at 2 y (n = 28)	High-Responders at 2 y (n = 29)	p Value
IFN-γ secretion (pg/ml), median (IQR)	18.64 (32.18)	24.23 (30.98)	0.119	22 (37.84)	17.15 (34.26)	33.16 (44.87)	0.025 (0.009^a)
IL-10 secretion (pg/ml), median (IQR)	32.11 (87.17)	82.32 (163.16)	0.05	35.09 (114.69)	79.87 (162.62)	79.06 (119.45)	0.112 (0.05^b, 0.069^c)
IL-13 secretion (pg/ml), median (IQR)	529.61 (1219.63)	978.30 (957.53)	0.125	796.25 (1104.05)	1157.21 (1313.74)	860.19 (988.54)	0.262
TNF-α secretion (pg/ml), median (IQR)	103.50 (131.24)	171.24 (209.45)	0.06	116.11 (161)	178.65 (231.64)	162.27 (175.13)	0.115 (0.032^c)

Nonresponders: anti-HBs levels <10 IU/l; low-responders: anti-HBs levels 10–100 IU/l; high-responders: anti-HBs levels ≥100 IU/l. Categorical data are presented as a number (%). The bold text indicates statistical significance.
^a Low-responders versus high-responders.
^b Nonresponders versus low-responders.
^c Nonresponders versus high-responders.