PT  - JOURNAL ARTICLE
AU  - Jensen, Isaac J.
AU  - Martin, Matthew D.
AU  - Tripathy, Sandeep K.
AU  - Badovinac, Vladimir P.
TI  - Novel Mouse Model of Murine Cytomegalovirus–Induced Adaptive NK Cells
AID  - 10.4049/immunohorizons.2100113
DP  - 2022 Jan 01
TA  - ImmunoHorizons
PG  - 8--15
VI  - 6
IP  - 1
4099  - http://www.immunohorizons.org/content/6/1/8.short
4100  - http://www.immunohorizons.org/content/6/1/8.full
AB  - NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of “Ag-specific” NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains that exhibit broad genetic diversity across strains. Our assessment identified and validated a putative “ideal” CC strain, CC006, which does not require manipulation to generate and maintain adaptive NK cells. Critically, CC006 mice, in contrast to C57BL/6 mice, are capable of developing enhanced NK cell–mediated protective responses to murine CMV infection following m157-mediated vaccination. This work both furthers our understanding of adaptive NK cells and demonstrates the utility of CC mice in the development and interrogation of immunologic models.