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Open Access

Depot Medroxyprogesterone Acetate Administration Alters Immune Markers for HIV Preference and Increases Susceptibility of Peripheral CD4+ T Cells to HIV Infection

Carley Tasker, Amy Davidow, Natalie E. Roche and Theresa L. Chang
ImmunoHorizons November 1, 2017, 1 (9) 223-235; DOI: https://doi.org/10.4049/immunohorizons.1700047
Carley Tasker
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103;
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Amy Davidow
Department of Preventive Medicine and Community Health, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103;
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Natalie E. Roche
Department of Obstetrics, Gynecology and Women’s Health, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103; and
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Theresa L. Chang
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103;Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103
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Abstract

Depot medroxyprogesterone acetate (Depo-Provera) has been associated with an increased risk of HIV acquisition. In a longitudinal study, we investigated the impact of Depo-Provera use by healthy women on expression of immune markers for HIV preference and on HIV infection ex vivo at baseline (visit 1), 1 mo (visit 2), and 3 mo (visit 3) after Depo-Provera treatment. We found a significant increase in the frequency and expression of integrin α4β7 on CD4+ T cells at visit 2. Interestingly, Hispanic but not black women exhibited a significant increase in integrin α4β7 cell numbers and expression levels at visit 2, whereas black but not Hispanic women exhibited a significant change in CCR5 and CD38 expression levels between visit 2 and visit 3. The frequency of terminal effector memory CD4+ T cells was decreased significantly in black women from visit 1 to visit 3. Virus production following ex vivo HIV infection of PBMCs was increased at visit 3 compared with visit 1. In black women, the frequency of HIV p24+CD4+ T cells was higher at visit 3 than at visit 1. Expression of integrin α4β7 on HIV p24+CD4+ T cells following ex vivo infection at visit 2 was significantly less than at visit 1. These results demonstrate that Depo-Provera alters the immune profile of peripheral CD4+ T cells and increases susceptibility to HIV infection ex vivo. The observation that these effects differed between women of different ethnicities has implications for developing effective and targeted strategies for HIV prevention.

Footnotes

  • This work was supported by National Institutes of Health Grant R01AI110372.

  • The online version of this article contains supplemental material.

  • Abbreviations used in this article:

    BMI
    body mass index
    CM
    central memory
    EM
    effector memory
    HIV-1
    HIV type 1
    IQR
    interquartile range
    MFI
    mean fluorescence intensity
    MOI
    multiplicity of infection
    MPA
    medroxyprogesterone acetate
    P4
    progesterone
    pDC
    plasmacytoid dendritic cell
    TEM
    terminal EM.

  • Received September 20, 2017.
  • Accepted October 30, 2017.
  • Copyright © 2017 The Authors

This article is distributed under the terms of the CC BY 4.0 Unported license.

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ImmunoHorizons: 1 (9)
ImmunoHorizons
Vol. 1, Issue 9
1 Nov 2017
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Depot Medroxyprogesterone Acetate Administration Alters Immune Markers for HIV Preference and Increases Susceptibility of Peripheral CD4+ T Cells to HIV Infection
Carley Tasker, Amy Davidow, Natalie E. Roche, Theresa L. Chang
ImmunoHorizons November 1, 2017, 1 (9) 223-235; DOI: 10.4049/immunohorizons.1700047

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Depot Medroxyprogesterone Acetate Administration Alters Immune Markers for HIV Preference and Increases Susceptibility of Peripheral CD4+ T Cells to HIV Infection
Carley Tasker, Amy Davidow, Natalie E. Roche, Theresa L. Chang
ImmunoHorizons November 1, 2017, 1 (9) 223-235; DOI: 10.4049/immunohorizons.1700047
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